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A 40-year-old woman who experiences severe seasonal allergies has been referred by her family physician to an allergist for weekly allergy injections.

A 40-year-old woman who experiences severe seasonal allergies has been referred by her family physician to an allergist for weekly allergy injections.

Question

Question 1.1. A 40-year-old woman who experiences severe seasonal allergies has been referred by her family physician to an allergist for weekly allergy injections. The woman is confused as to why repeated exposure to substances that set off her allergies would ultimately benefit her. Which of the following phenomena best captures the rationale for allergy desensitization therapy? (Points : 3)

Repeated exposure to offending allergens binds the basophils and mast cells that mediate the allergic response.

Exposure to allergens in large, regular quantities overwhelms the IgE antibodies that mediate the allergic response.

Repeated exposure stimulates adrenal production of epinephrine, mitigating the allergic response.

Injections of allergens simulate production of IgG, which blocks antigens from combining with IgE.

Question 2.2. A 14-year-old boy has been diagnosed with infectious mononucleosis. Which of the following pathophysiological phenomena is most responsible for his symptoms? (Points : 3)

The Epstein-Barr virus (EBV) is lysing many of the boy’s neutrophils.

Viruses are killing some of his B cells and becoming incorporated into the genomes of others.

The EBV inhibits the maturation of white cells within his peripheral lymph nodes.

The virus responsible for mononucleosis inhibits the maturation of myeloblasts into promyelocytes.

Question 3.3. A 66-year-old female patient has presented to the emergency department because of several months of intermittently bloody stools that has recently become worse.

The woman has since been diagnosed with a gastrointestinal bleed secondary to overuse of nonsteroidal anti-inflammatory drugs that she takes for her arthritis. The health care team would realize that which of the following situations is most likely?(Points : 3)

The woman has depleted blood volume due to her ongoing blood loss.

She will have iron-deficiency anemia due to depletion of iron stores.

The patient will be at risk for cardiovascular collapse or shock.

She will have delayed reticulocyte release.

Question 4.4. Which of the following patients is most likely to benefit from transplantation of thymic tissue or major histocompatibility complex (MHC)-compatible bone marrow? (Points : 3)

A 12-year-old girl with a history of epilepsy and low IgG levels secondary to phenytoin use

A 7-year-old boy whose blood work indicates decreased IgA and IgG with increased IgM

A 6-year-old boy whose pre-B cells are incapable of translation to normal B cells

A 9-year-old girl who has a diagnosis of IgA deficiency

Question 5.5. A 29-year-old construction worker got a sliver under his fingernail four days ago. The affected finger is now reddened, painful, swollen, and warm to the touch. Which of the following hematological processes is most likely occurring in response to the infection? (Points : 3)

Proliferation of immature neutrophils

High circulatory levels of myeloblasts

Increased segmented neutrophil production

Phagocytosis by myelocytes


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